Our lab is interested in the cell biology of a family of enzymes called tyrosine phosphatases. This large family of enzymes has been understudied compared to its more famous kinase counterpart. We use different model systems and experimental approaches to understand tyrosine phosphatase function, in particular how they regulate the actin cytoskeleton.

Tyrosine phosphorylation of signalling proteins controls essential actin-dependent processes including migration, adhesion, and communication. Several pathogens also hijack these pathways to promote their own spread. We study tyrosine phosphatases in Vaccinia virus-infected cells. We also use the genetic model system C. elegans to understand these enzymes in an organismal context.

We are part of the Randall Centre for Cell and Molecular Biophysics, King's College London, and are funded by a Career Development Award from the Wellcome Trust. You can find us on the 2nd floor of New Hunt's House, Guy's Campus.

Please contact Angika for any queries angika [dot] basant [at] kcl [dot] ac [dot] uk