Localisation and signalling dynamics
We use fixed and live imaging approaches to investigate the spatiotemporal localisation of tyrosine phosphatases, and their impact on other cellular structures and dynamic events such as Vaccinia virus motility.
We use fixed and live imaging approaches to investigate the spatiotemporal localisation of tyrosine phosphatases, and their impact on other cellular structures and dynamic events such as Vaccinia virus motility.
Interactors, substrates and phosphoregulation
We use unbiased proteomic approaches as well as targeted strategies to study the interactomes and phosphorylation patterns of specific phosphatases. We compare data from uninfected and Vaccinia-infected cells, across wildtype and mutant phosphatases.
We use unbiased proteomic approaches as well as targeted strategies to study the interactomes and phosphorylation patterns of specific phosphatases. We compare data from uninfected and Vaccinia-infected cells, across wildtype and mutant phosphatases.
Organismal context
We take advantage of the genetic model organism C. elegans to understand tyrosine phosphatases in live animals. We are currently exploring tyrosine phosphatases that localise and function in the large and polarised intestinal epithelial cells of the worm.
We take advantage of the genetic model organism C. elegans to understand tyrosine phosphatases in live animals. We are currently exploring tyrosine phosphatases that localise and function in the large and polarised intestinal epithelial cells of the worm.